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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PTPN22
All Species:
9.09
Human Site:
S585
Identified Species:
20
UniProt:
Q9Y2R2
Number Species:
10
Phosphosite Substitution
Charge Score:
0.2
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y2R2
NP_057051.3
807
91705
S585
Y
N
S
H
D
S
L
S
L
N
S
P
T
N
I
Chimpanzee
Pan troglodytes
XP_513663
807
91678
S585
Y
N
S
N
D
S
L
S
L
N
S
P
T
N
I
Rhesus Macaque
Macaca mulatta
XP_001110241
807
91482
S585
Y
N
S
H
D
S
L
S
L
N
S
P
T
N
I
Dog
Lupus familis
XP_540240
893
101055
A670
Y
N
S
H
D
S
L
A
L
S
P
P
T
D
D
Cat
Felis silvestris
Mouse
Mus musculus
P29352
802
89696
D581
F
F
Y
S
N
P
H
D
S
L
V
M
N
T
L
Rat
Rattus norvegicus
NP_001099930
804
89584
P581
A
S
S
S
Y
S
N
P
R
D
S
L
M
E
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506530
800
89754
H575
S
V
P
C
G
S
Q
H
C
L
P
A
S
E
P
Chicken
Gallus gallus
XP_001235234
775
85980
L555
C
T
V
P
T
S
P
L
L
Q
P
A
S
H
H
Frog
Xenopus laevis
NP_001084841
660
74123
A440
E
S
P
K
S
F
E
A
S
A
G
L
Q
R
G
Zebra Danio
Brachydanio rerio
NP_956963
570
64484
E350
Q
G
E
C
A
V
Q
E
E
I
L
Q
A
P
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_796904
967
106580
P604
P
S
Q
P
P
P
K
P
P
A
S
A
K
P
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
95.5
71.1
N.A.
71.1
69.2
N.A.
57.1
50.8
36.3
34.3
N.A.
N.A.
N.A.
N.A.
28.2
Protein Similarity:
100
99.8
97
77.9
N.A.
80.4
79.3
N.A.
68
64
50.9
49.9
N.A.
N.A.
N.A.
N.A.
44.7
P-Site Identity:
100
93.3
100
66.6
N.A.
0
20
N.A.
6.6
13.3
0
0
N.A.
N.A.
N.A.
N.A.
6.6
P-Site Similarity:
100
100
100
86.6
N.A.
20
33.3
N.A.
13.3
26.6
13.3
0
N.A.
N.A.
N.A.
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
0
0
0
10
0
0
19
0
19
0
28
10
0
0
% A
% Cys:
10
0
0
19
0
0
0
0
10
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
37
0
0
10
0
10
0
0
0
10
10
% D
% Glu:
10
0
10
0
0
0
10
10
10
0
0
0
0
19
10
% E
% Phe:
10
10
0
0
0
10
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
10
0
0
10
0
0
0
0
0
10
0
0
0
10
% G
% His:
0
0
0
28
0
0
10
10
0
0
0
0
0
10
10
% H
% Ile:
0
0
0
0
0
0
0
0
0
10
0
0
0
0
28
% I
% Lys:
0
0
0
10
0
0
10
0
0
0
0
0
10
0
0
% K
% Leu:
0
0
0
0
0
0
37
10
46
19
10
19
0
0
10
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
10
10
0
0
% M
% Asn:
0
37
0
10
10
0
10
0
0
28
0
0
10
28
0
% N
% Pro:
10
0
19
19
10
19
10
19
10
0
28
37
0
19
19
% P
% Gln:
10
0
10
0
0
0
19
0
0
10
0
10
10
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
10
0
0
0
0
10
0
% R
% Ser:
10
28
46
19
10
64
0
28
19
10
46
0
19
0
10
% S
% Thr:
0
10
0
0
10
0
0
0
0
0
0
0
37
10
0
% T
% Val:
0
10
10
0
0
10
0
0
0
0
10
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
37
0
10
0
10
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _